Résumé :
|
[BDSP. Notice produite par INPES kq8nR0xp. Diffusion soumise à autorisation]. Background : Electronic cigarettes (e-cigarettes) can deliver nicotine and mitigate tobacco withdrawal and are used by many smokers to assist quit attempts. We investigated whether e-cigarettes are more effective than nicotine patches at helping smokers to quit. Methods : We did this pragmatic randomised-controlled superiority trial in Auckland, New Zealand, between Sept 6,2011, and July 5,2013. Adult (=18 years) smokers wanting to quit were randomised (with computerised block randomisation, block size nine, stratified by ethnicity [Maori ; Pacific ; or non-Maori, non-Pacific], sex [men or women], and level of nicotine dependence [>5 or=5 Fagerström test for nicotine dependence]) in a 4 : 4 : 1 ratio to 16 mg nicotine e-cigarettes, nicotine patches (21 mg patch, one daily), or placebo e-cigarettes (no nicotine), from 1 week before until 12 weeks after quit day, with low intensity behavioural support via voluntary telephone counselling. The primary outcome was biochemically verified continuous abstinence at 6 months (exhaled breath carbon monoxide measurement
|