Titre :
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Hippocampal Atrophy and Subsequent Depressive Symptoms in Older Men and Women : Results From a 10-Year Prospective Cohort (2014)
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Auteurs :
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Martine ELBEJJANI ;
Rebecca FUHRER ;
Department of Epidemiology. Biostatistics. And Occupational Health, McGill University (Montreal PQ, Canada) ;
Michal ABRAHAMOWICZ ;
Centre National de la Recherche Scientifique, Unite Mixte Recherche 5296 (Bordeaux, France) ;
Bernard MAZOYER ;
Commissariat à l'Energie Atomique, Unité Mixte Recherche 5296 (Bordeaux, France) ;
Fabrice CRIVELLO ;
Bordeaux University (Bordeaux, France) ;
Inserm U897-Epidemiology and Biostatistics (Bordeaux, France) ;
Christophe TZOURIO ;
Carole DUFOUIL
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 180, n° 4, août 2014)
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Pagination :
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385-393
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Langues:
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Anglais
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Mots-clés :
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Etat dépressif
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Evolution
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Personne âgée
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Femme
;
Sexe
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Résultat
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Etude prospective
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Vieillissement
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Imagerie médicale
;
Epidémiologie
;
Homme
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Résumé :
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[BDSP. Notice produite par INIST-CNRS mR0xkpDk. Diffusion soumise à autorisation]. Several studies have reported smaller hippocampal volume in patients with depression. However, the temporality of the association is undetermined. One hypothesis is that hippocampal atrophy might be a susceptibility factor for depression. In the present study, we assessed whether hippocampal atrophy was associated with subsequent depressive symptoms in a cohort of older French adults (n=1,309) who were 65-80 years of age and enrolled into the study in 1999-2001 in Dijon, France. Subjects were followed for more than 10 years. Participants underwent 2 cerebral magnetic resonance imaging scans, one at baseline and one at the 4-year follow-up. We used linear mixed models to estimate the associations of hippocampal atrophy with 1) the average depressive symptom scores over follow-up (using the Center for Epidemiologic Studies-Depression scale) measured biennially over the subsequent 6 years and 2) changes in symptom scores over follow-up. In women, a 2-standard-deviation increase in annual hippocampal atrophy was associated with a 1.67-point (95% confidence interval : 0.59,2.77) increase in the average depressive symptom score over follow-up and with a 1.97-point (95% confidence interval : 0.68,3.24) increase in scores over the 2 subsequent years but not with later changes in symptoms. No association was detected in men. Accounting for potential selective attrition (using inverse probability weights) did not alter results. Hippocampal atrophy was associated with more subsequent depressive symptoms and with shorter-term worsening of symptoms in women.
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