Titre :
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Suicide Mortality in Relation to Dietary Intake of n-3 and n-6 Polyunsaturated Fatty Acids and Fish : Equivocal Findings From 3 Large US Cohort Studies (2014)
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Auteurs :
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Alexander-C TSAI ;
Michel Lucas ;
Department of Psychiatry, Harvard Medical School (Boston MA, Etats-Unis) ;
Olivia-I OKEREKE ;
Department of Nutrition, Harvard School of Public Health (Boston MA, Etats-Unis) ;
Eilis-J O'REILLY ;
Channing Division of Network Medicine, Brigham and Women's Hospital (Boston MA, Etats-Unis) ;
Department of Epidemiology, Harvard School of Public Health (Boston MA, Etats-Unis) ;
Fariba MIRZAEI ;
Ichiro Kawachi ;
Alberto ASCHERIO ;
Walter-C Willett
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 179, n° 12, juin 2014)
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Pagination :
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1458-1466
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Langues:
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Anglais
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Mots-clés :
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Facteur risque
;
Suicide
;
Homme
;
Epidémiologie
;
Mortalité
;
Régime alimentaire
;
Alimentation
;
Aliment
;
Femme
;
Amérique
;
Poisson
;
Amérique du Nord
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Résumé :
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[BDSP. Notice produite par INIST-CNRS klR0xEGE. Diffusion soumise à autorisation]. Intake of n-3 and n-6 polyunsaturated fatty acids (PUFAs) has been implicated in the pathogenesis of depression. We sought to estimate the association between intake of fish and n-3 and n-6 PUFAs and suicide mortality over the course of long-term follow-up. In this prospective cohort study, biennial questionnaires were administered to 42,290 men enrolled in the Health Professionals Follow-up Study (1988-2008), 72,231 women enrolled in the Nurses'Health Study (1986-2008), and 90,836 women enrolled in Nurses'Health Study II (1993-2007). Dietary fish and n-3 and n-6 PUFA intakes were assessed every 4 years using a validated food-frequency questionnaire. Suicide mortality was ascertained through blind physician review of death certificates and hospital or pathology reports. Adjusted relative risks of suicide mortality were estimated with multivariable Cox proportional hazards models and pooled across cohorts using random-effects meta-analysis. The pooled multivariable relative risks for suicide among persons in the highest quartile of intake of n-3 or n-6 PUFAs, relative to the lowest quartile, ranged from 1.08 to 1.46 for n-3 PUFAs (Ptrend=0.11-0.52) and from 0.68 to 1.19 for n-6 PUFAs (Ptrend=0.09-0.54). We did not find evidence that intake of n-3 PUFAs or fish lowered the risk of completed suicide.
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