Résumé :
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[BDSP. Notice produite par INIST-CNRS DrIR0xHm. Diffusion soumise à autorisation]. Aggressively managing low-density lipoprotein cholesterol (LDL-C) after myocardial infarction (MI) is a corner-stone of secondary prevention. The changes in LDL-C after MI and the factors associated with LDL-C levels are unknown. Therefore, we directly measured fasting LDL-C levels in 797 MI patients from 24 US hospitals from 2005 to 2008. Mean LDL-C levels at discharge, 1 month, and 6 months were 95.1,81.9, and 87.1 mg/dL, respectively. In a hierarchical, multivariable, repeated measures model, older age, male sex, and hypertension were associated with lower LDL-C levels, whereas self-reported avoidance of health care because of cost was associated with higher LDL-C. Both the presence and intensity of statin therapy at discharge were strongly associated with LDL-C levels, with adjusted mean 6-month changes of - 3.4 mg/dL (95% confidence interval (CI) : - 12.1,5.3) for no statins ; 1.7 mg/dL (95% CI : - 4.7,8.1) for low statins ; - 10.2 mg/dL (95% CI : - 14.5, - 6.0) for moderate statins ; and - 13.9 mg/dL (95% CI : - 19.7, - 8.0) for intensive statins (P
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