Résumé :
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[BDSP. Notice produite par INIST-CNRS 887R0xFk. Diffusion soumise à autorisation]. The pathophysiological consequences of caregiving have not been fully elucidated. We evaluated how caregiving, stress, and caregiver strain were associated with shorter relative telomere length (RTL), a marker of cellular aging. Caregivers (n=240) and some noncaregivers (n=98) in the 2008-2010 Survey of the Health of Wisconsin, comprising a representative sample of Wisconsin adults aged 21-74 years, reported their sociodemographic, health, and psychological characteristics. RTL was assayed from blood or saliva samples. Median T and S values were used to determine the telomere-to-single copy gene ratio (T/S) for each sample, and log (T/S) was used as the dependent variable in analyses. Multivariable generalized additive models showed that RTL did not differ between caregivers and noncaregivers (difference in log (T/S)=-0.03 ; P>0.05), but moderate-to-high levels of stress versus low stress were associated with longer RTL (difference=0.15 ; P=0.04). Among caregivers, more hours per week of care, caring for a young person, and greater strain were associated with shorter RTL (P
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