Titre :
|
No Rise in Incidence but Geographical Heterogeneity in the Occurrence of Primary Biliary Cirrhosis in North East England (2014)
|
Auteurs :
|
Richard-Jq MCNALLY ;
Peter-W JAMES ;
Institute of Health and Society, Newcastle University (Newcastle upon Tyne, Royaume-uni) ;
Samantha DUCKER ;
Institute of Cellular Medicine, Newcastle University (Newcastle upon Tyne, Royaume-uni) ;
Paul-D NORMAN ;
Oliver-Fw JAMES
|
Type de document :
|
Article
|
Dans :
|
American journal of epidemiology (vol. 179, n° 4, février 2014)
|
Pagination :
|
492-498
|
Langues:
|
Anglais
|
Mots-clés :
|
Incidence
;
Angleterre
;
Environnement
;
Etiologie
;
Epidémiologie
;
Grande Bretagne
;
Europe
|
Résumé :
|
[BDSP. Notice produite par INIST-CNRS GBCpnR0x. Diffusion soumise à autorisation]. In this study, we examined temporal changes in the incidence of primary biliary cirrhosis (PBC) and investigated associations between PBC incidence and sociodemographic factors and spatial clustering. We included 982 patients aged>=40 years from North East England with incident PBC diagnosed during 1987-2003. Age-standardized incidence rates with 95% confidence intervals were calculated. Negative binomial regression was used to analyze incidence and socioeconomic deprivation. Clustering analysis was performed using point process methods, testing the null hypothesis that disease risk does not vary spatially and that PBC cases occur independently. The age-standardized incidence rate was 53.50 per million persons per year (95% confidence interval : 48.65,58.35) in 1987-1994 and 45.09 per million persons per year (95% confidence interval : 41.10,49.07) in 1995-2003. Risk of PBC increased in areas with higher levels of socioeconomic deprivation (P=0.035). More specifically, risk increased in areas with higher levels of overcrowded homes (P=0.040), higher levels of households without cars (P
|