Titre :
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Effect Modification of the Association of Cumulative Exposure and Cancer Risk by Intensity of Exposure and Time Since Exposure Cessation : A Flexible Method Applied to Cigarette Smoking and Lung Cancer in the SYNERGY Study (2014)
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Auteurs :
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Jelle VLAANDEREN ;
Lützen PORTENGEN ;
Joachim SCHUZ ;
Ann OLSSON ;
Beate PESCH ;
Benjamin KENDZIA ;
Isabelle STUCKER ;
Florence GUIDA ;
Irene BRUSKE ;
Heinz-Erich WICHMANN ;
Dario CONSONNI ;
Maria-Teresa LANDI ;
Neil CAPORASO ;
Jack SIEMIATYCKI ;
Franco MERLETTI ;
Dario MIRABELLI ;
Lorenzo RICHIARDI ;
Per GUSTAVSSON ;
Nils PLATO ;
Karl-Heinz JOCKEL ;
Wolfgang Ahrens ;
Hermann POHLABELN ;
Adonina TARDON ;
David ZARIDZE ;
John-K FIELD ;
Andrea-'t MANNETJE ;
Neil PEARCE ;
John MCLAUGHLIN ;
Paul Demers ;
Neonila SZESZENIA-DABROWSKA ;
Jolanta LISSOWSKA ;
Peter RUDNAI ;
Eleonora FABIANOVA ;
Rodica-Stanescu DUMITRU ;
Vladimir BENCKO ;
Lenka FORETOVA ;
Vladimir JANOUT ;
Paolo BOFFETTA ;
Francesco FORASTIERE ;
Bas BUENO-DE-MESQUITA ;
Susan Peters ;
Thomas BRUNING ;
Hans KROMHOUT ;
Kurt STRAIF ;
Roel VERMEULEN
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 179, n° 3, février 2014)
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Pagination :
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290-298
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Langues:
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Anglais
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Mots-clés :
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Cancer
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Tabagisme
;
Modification
;
Risque cumulé
;
Facteur associé
;
Association
;
Exposition
;
Facteur risque
;
Risque
;
Durée exposition
;
Arrêt
;
Méthode
;
Méthodologie
;
Cigarette
;
Tabac
;
Epidémiologie
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Résumé :
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[BDSP. Notice produite par INIST-CNRS GR0xED8E. Diffusion soumise à autorisation]. The indiscriminate use of the cumulative exposure metric (the product of intensity and duration of exposure) might bias reported associations between exposure to hazardous agents and cancer risk. To assess the independent effects of duration and intensity of exposure on cancer risk, we explored effect modification of the association of cumulative exposure and cancer risk by intensity of exposure. We applied a flexible excess odds ratio model that is linear in cumulative exposure but potentially nonlinear in intensity of exposure to 15 case-control studies of cigarette smoking and lung cancer (1985-2009). Our model accommodated modification of the excess odds ratio per pack-year of cigarette smoking by time since smoking cessation among former smokers. We observed negative effect modification of the association of pack-years of cigarette smoking and lung cancer by intensity of cigarette smoke for persons who smoked more than 20-30 cigarettes per day. Patterns of effect modification were similar across individual studies and across major lung cancer subtypes. We observed strong negative effect modification by time since smoking cessation. Application of our method in this example of cigarette smoking and lung cancer demonstrated that reducing a complex exposure history to a metric such as cumulative exposure is too restrictive.
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