Résumé :
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[BDSP. Notice produite par INIST-CNRS GR0xmG88. Diffusion soumise à autorisation]. We wanted to compare cancer incidence rates between Parkinson's disease (PD) patients and persons without PD, as well as between siblings of these groups. We conducted a family-based matched cohort study based on nationwide Swedish health registries and the Swedish Multi-Generation Register. We assessed risk of incident cancer in PD patients (n=11,786) during 1964-2009 versus a matched cohort of PD-free individuals (n=58,930) and in siblings of PD patients (n=16,841) versus siblings of PD-free individuals (n=84,205). Hazard ratios with 95% confidence intervals were estimated using Cox proportional hazards regression. Cancer occurrence was slightly higher in PD patients than in PD-free individuals (hazard ratio (HR)=1.05,95% confidence interval (CI) : 1.00,1.10), largely because of cancers arising within 1 year before or after the index date for PD, but risk of smoking-related cancers was lower (HR=0.87,95% CI : 0.79,0.96). PD patients had a higher risk of melanoma both up to 1 year before the PD index date (HR=1.53,95% CI : 1.23,1.91) and from 1 year after the index date onward (HR=1.46,95% CI : 1.01,2.10). In the sibling comparison, cancer occurrence was largely similar. These results indicate that melanoma risk is higher among PD patients and that mechanisms other than familial ones explain the association.
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