Titre :
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Levels of Cotinine in Dried Blood Specimens from Newborns as a Biomarker of Maternal Smoking Close to the Time of Delivery (2013)
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Auteurs :
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. JUAN YANG ;
Michelle PEARL ;
Sequoia Foundation (Richmond CA, Etats-Unis) ;
Division of Clinical Pharmacology and Experimental Therapeutics, University of California (San Francisco CA, Etats-Unis) ;
Peyton-Iii Jacob ;
Gerald-N DELORENZE ;
Neal-L BENOWITZ ;
Lisa YU ;
Christopher HAVEL ;
Martin KHARRAZI
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 178, n° 11)
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Pagination :
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1648-1654
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Langues:
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Anglais
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Mots-clés :
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Tabagisme
;
Accouchement
;
Marqueur tabagisme
;
Sang
;
Nouveau né
;
Mère
;
Tabac
;
Grossesse
;
Femme
;
Femme enceinte
;
Epidémiologie
;
Amérique
;
Homme
;
Amérique du Nord
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Résumé :
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[BDSP. Notice produite par INIST-CNRS oER0x8ns. Diffusion soumise à autorisation]. The precise quantitation of smoking during pregnancy is difficult in retrospective studies. Routinely collected blood specimens from newborns, stored as dried blood spots, may provide a low-cost method to objectively measure maternal smoking close to the time of delivery. This article compares cotinine levels in dried blood spots to those in umbilical cord blood to assess cotinine in dried blood spots as a biomarker of maternal smoking close to the time of delivery. The California Genetic Disease Screening Program provided dried blood spots from 428 newborns delivered in 2001-2003 with known umbilical cord blood cotinine levels. Cotinine in dried blood spots was measured in 6.35-mm punches by using liquid chromatography-tandem mass spectrometry (quantitation limit, 3.1 ng/mL). Repeated measures of cotinine in dried blood spots were highly correlated (R2=0.99, P
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