Résumé :
|
[BDSP. Notice produite par INIST-CNRS R0xCnG8E. Diffusion soumise à autorisation]. The risk of lung cancer among night-shift workers is unknown. Over 20 years of follow-up (1988-2008), we documented 1,455 incident lung cancers among 78,612 women in the Nurses'Health Study. To examine the relationship between rotating night-shift work and lung cancer risk, we used multivariate Cox proportional hazard models adjusted for detailed smoking characteristics and other risk factors. We observed a 28% increased risk of lung cancer among women with 15 or more years spent working rotating night shifts (multivariate relative risk (RR)=1.28,95% confidence interval (CI) : 1.07,1.53 ; P trend=0.03) compared with women who did not work any night shifts. This association was strongest for small-cell lung carcinomas (multivariate RR=1.56,95% CI : 0.99,2.47 ; P trend=0.03) and was not observed for adenocarcinomas of the lung (multivariate RR=0.91,95% CI : 0.67,1.24 ; P trend=0.40). Further, the increased risk associated with 15 or more years of rotating night-shift work was limited to current smokers (RR=1.61,95% CI : 1.21,2.13 ; P trend
|