Titre : | Exposure-Response Analysis and Risk Assessment for Lung Cancer in Relationship to Silica Exposure : A 44-Year Cohort Study of 34,018 Workers (2013) |
Auteurs : | . YUEWEI LIU ; Department of Occupational and Environmental Health. School of Public Health. Tongji Medical College. Huazhong University of Science and Technology, Wuhan (Hubei, Chine) ; Kyle STEENLAND ; Key Laboratory of Environment and Health. Ministry of Education and Ministry of Environmental Protection. And State Key Laboratory of Environmental Health. School of Public Health. Tongji Medical College, Huazhong University of Science and Technology (Wuhan Hubei, Chine) ; . YI RONG ; Eva HNIZDO ; Institute of Health Surveillance. Analysis and Protection. Hubei Center for Disease Control and Prevention, Wuhan (Hubei, Chine) ; . XIJI HUANG ; . HAI ZHANG ; . TINGMING SHI ; . YI SUN ; . TANGCHUN WU ; . WEIHONG CHEN |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 178, n° 9, 2013) |
Pagination : | 1424-1433 |
Langues: | Anglais |
Mots-clés : | Silicose ; Exposition ; Facteur risque ; Risque ; Silice ; Ouvrier ; Homme ; Epidémiologie ; Cancer ; Maladie professionnelle ; Pneumoconiose |
Résumé : | [BDSP. Notice produite par INIST-CNRS 9prR0xEk. Diffusion soumise à autorisation]. Crystalline silica has been classified as a human carcinogen by the International Agency for Research on Cancer (Lyon, France) ; however, few previous studies have provided quantitative data on silica exposure, silicosis, and/or smoking. We investigated a cohort in China (in 1960-2003) of 34,018 workers without exposure to carcinogenic confounders. Cumulative silica exposure was estimated by linking a job-exposure matrix to work history. Cox proportional hazards model was used to conduct exposure-response analysis and risk assessment. During a mean 34.5-year follow-up, 546 lung cancer deaths were identified. Categorical analyses by quartiles of cumulative silica exposure (using a 25-year lag) yielded hazard ratios of 1.26,1.54,1.68, and 1.70, respectively, compared with the unexposed group. Monotonic exposure-response trends were observed among nonsilicotics (Pfor trend |