Titre :
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A Prospective Study of Circulating C-Reactive Protein, Interleukin-6, and Tumor Necrosis Factor alpha Receptor 2 Levels and Risk of Ovarian Cancer (2013)
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Auteurs :
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Elizabeth-M POOLE ;
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School (Boston MA, Etats-Unis) ;
I-Min LEE ;
Division of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School (Boston MA, Etats-Unis) ;
Paul-M RIDKER ;
Department of Epidemiology, Harvard School of Public Health (Boston MA, Etats-Unis) ;
Julie-E Buring ;
Susan-E HANKINSON ;
Shelley-S TWOROGER
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 178, n° 8, Octobre 2013)
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Pagination :
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1256-1264
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Langues:
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Anglais
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Mots-clés :
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Etude prospective
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Facteur risque
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Risque
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Epidémiologie
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Cancer
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Résumé :
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[BDSP. Notice produite par INIST-CNRS tsBHR0x9. Diffusion soumise à autorisation]. Chronic inflammation may play a role in ovarian carcinogenesis. We examined associations between 3 plasma biomarkers of inflammation-C-reactive protein (CRP), interleukin 6, and tumor necrosis factor alpha receptor 2-and risk of invasive epithelial ovarian cancer in prospectively collected samples from the Nurses'Health Study (NHS ; 1989-2010), Nurses'Health Study II (NHS II ; 1996-2009), and the Women's Health Study (WHS ; 1992-2011) and performed a meta-analysis including data from previous publications. Associations with ovarian cancer risk were calculated using logistic regression (NHS/NHS II ; n=217 cases) or Cox proportional hazards regression (WHS ; n=159 cases). Study-specific results were combined using random-effects meta-analysis. In the NHS/NHS II and WHS, we observed a 53% increased risk of invasive ovarian cancer when comparing women in the fourth quartile of CRP with women in the first quartile (95% confidence interval (CI) : 1.05,2.23). A CRP level of>10 mg/L versus a level of
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