| Titre : | Dietary Flavonoid Intake and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition Cohort (2013) |
| Auteurs : | Esther VERMEULEN ; Raul ZAMORA-ROS ; Eric-J DUELL ; Leila LUJAN-BARROSO ; Heiner BOEING ; Krasimira ALEKSANDROVA ; Hbas BUENO-DE-MESQUITA ; Augustin SCALBERT ; Isabelle ROMIEU ; Veronika FEDIRKO ; Marina TOUILLAUD ; Guy FAGHERAZZI ; Florence PERQUIER ; Esther MOLINA-MONTES ; Maria-Dolores CHIRLAQUE ; Marcial-Vicente ARGUELLES ; Pilar AMIANO ; Aurelio BARRICARTE ; Valeria PALA ; Amalia MATTIELLO ; Calogero SAIEVA ; Rosario TUMINO ; Fulvio RICCERI ; Antonia TRICHOPOULOU ; Effie VASILOPOULOU ; Gianna ZIARA ; Francesca-L CROWE ; Kay-Thee Khaw ; Nicholas-J WAREHAM ; Annekatrin LUKANOVA ; Verena-A GROTE ; Anne TJONNELAND ; Jytte HALKJAER ; Lea BREDSDORFF ; Kim OVERVAD ; Peter-D SIERSEMA ; Petra-Hm PEETERS ; Anne-M MAY ; Elisabete WEIDERPASS ; Guri SKEIE ; Anette HJARTAKER ; Rikard LANDBERG ; Ingegerd JOHANSSON ; Emily SONESTEDT ; Ulrika ERICSON ; Elio RIBOLI ; Carlos-A GONZALEZ |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 178, n° 4, 2013) |
| Pagination : | 570-581 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Régime alimentaire ; Alimentation ; Aliment ; Facteur risque ; Risque ; Europe ; Etude prospective ; Nutrition ; Epidémiologie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xmEE98. Diffusion soumise à autorisation]. We prospectively investigated dietary flavonoid intake and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 477,312 adult subjects from 10 European countries. At baseline, country-specific validated dietary questionnaires were used. During a mean follow-up of 11 years (1992-2010), there were 341 incident esophageal cancer cases, of which 142 were esophageal adenocarcinoma (EAC), 176 were esophageal squamous cell carcinoma (ESCC), and 23 were other types of esophageal cancer. In crude models, a doubling in total dietary flavonoid intake was inversely associated with esophageal cancer risk (hazard ratio (HR) (log2)=0.87,95% confidence interval (CI) : 0.78,0.98) but not in multivariable models (HR (log2)=0.97,95% CI : 0.86,1.10). After covariate adjustment, no statistically significant association was found between any flavonoid subclass and esophageal cancer, EAC, or ESCC. |
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