Titre :
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Associations Between Metabolomic Compounds and Incident Heart Failure Among African Americans : The ARIC Study (2013)
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Auteurs :
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. YAN ZHENG ;
. BING YU ;
Department of Epidemiology Human Genetics And Environmental Sciences, University of Texas Health Science Center at Houston (Houston TX, Etats-Unis) ;
Danny ALEXANDER ;
Teri-A MANOLIO ;
David AGUILAR ;
Josef CORESH ;
Gerardo HEISS ;
Eric BOERWINKLE ;
Jennifer-A NETTLETON
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Type de document :
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Article
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Dans :
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American journal of epidemiology (vol. 178, n° 4, 2013)
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Pagination :
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534-542
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Langues:
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Anglais
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Mots-clés :
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Insuffisance cardiaque
;
Artériosclérose
;
Facteur associé
;
Association
;
Incidence
;
Homme
;
Facteur risque
;
Epidémiologie
;
Amérique
;
Cardiopathie
;
Amérique du Nord
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Résumé :
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[BDSP. Notice produite par INIST-CNRS B8DR0xAk. Diffusion soumise à autorisation]. Heart failure is more prevalent among African Americans than in the general population. Metabolomic studies among African Americans may efficiently identify novel biomarkers of heart failure. We used untargeted methods to measure 204 stable serum metabolites and evaluated their associations with incident heart failure hospitalization (n=276) after a median follow-up of 20 years (1987-2008) by using Cox regression in data from 1,744 African Americans aged 45-64 years without heart failure at baseline from the Jackson, Mississippi, field center of the Atherosclerosis Risk in Communities (ARIC) Study. After adjustment for established risk factors, we found that 16 metabolites (6 named with known structural identities and 10 unnamed with unknown structural identities, the latter denoted by using the format X-12345) were associated with incident heart failure (P
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