Résumé :
|
[BDSP. Notice produite par INIST-CNRS R0xC7mDA. Diffusion soumise à autorisation]. Risk factor associations for rare breast cancer variants are often imprecise, obscuring differences between tumor types. To clarify differences, we examined risk factors for 5 histological types of breast cancer in the National Institutes of Health-AARP Diet and Health Study. Risk factor information was self-reported. We followed 192,076 postmenopausal women aged 50-71 years from 1995-1996 through 2006. During that time period, 5,334 ductal, 836 lobular, 639 mixed ductal-lobular, 216 mucinous, and 132 tubular breast cancers were diagnosed. Hazard ratios and 95% confidence intervals were estimated using Cox proportional hazards regression. Heterogeneity was evaluated using case-only logistic regression. The strongest differences were for menopausal hormone therapy (Pheterogeneity=30 years vs. 20-24 years, HR=0.62,95% CI : 0.27,1.42) or tubular (HR=1.08,95% CI : 0.51,2.29) tumors, in contrast to clear positive associations with lobular (HR=1.82,95% CI : 1.39,2.37) and mixed ductal-lobular (HR=1.87,95% CI : 1.39,2.51) tumors. Differing associations for hormonal factors and mucinous and tubular cancers suggest etiologies distinct from those of common breast cancers.
|