Titre : | The Association of Plasma Lactate With Incident Cardiovascular Outcomes : The ARIC Study (2013) |
Auteurs : | Kunihiro MATSUSHITA ; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health (Baltimore MD, Etats-Unis) ; Emma-K Williams ; Division of General Internal Medicine, Johns Hopkins University (Baltimore MD, Etats-Unis) ; Morgana-L MONGRAW-CHAFFIN ; Josef CORESH ; Department of Medicine, Baylor College of Medicine and Methdodist DeBakey Heart and Vascular Center (Houston TX, Etats-Unis) ; Maria-Ines SCHMIDT ; Frederick-L BRANCATI ; Ron-C HOOGEVEEN ; Christie-M BALLANTYNE ; Jhunter YOUNG |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 178, n° 3, Août 2013) |
Pagination : | 401-409 |
Langues: | Anglais |
Mots-clés : | Artériosclérose ; Insuffisance cardiaque ; Association ; Plasma sanguin ; Incidence ; Pronostic ; Epidémiologie ; Amérique ; Cardiopathie ; Amérique du Nord |
Résumé : | [BDSP. Notice produite par INIST-CNRS R0xso898. Diffusion soumise à autorisation]. We examined the association of plasma lactate at rest, a marker of oxidative capacity, with incident cardiovascular outcomes in 10,006 participants in the Atherosclerosis Risk in Communities (ARIC) Study visit 4 (1996-1998). We used Cox proportional-hazards models to estimate hazard ratios of incident coronary heart disease, stroke, heart failure, and all-cause mortality by quartiles of plasma lactate (Q1,=8.7). During a median follow-up time of 10.7 years, there were 1,105 coronary heart disease cases, 379 stroke cases, 820 heart failure cases, and 1,408 deaths. A significant graded relation between lactate level and cardiovascular events was observed in the demographically adjusted model (all P for trend |