Résumé :
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[BDSP. Notice produite par INIST-CNRS DR0x8t78. Diffusion soumise à autorisation]. Vitamin D may reduce telomere shortening through anti-inflammatory and anti-cell proliferation mechanisms. In the present study, we examined the association between vitamin D and relative leukocyte telomere length by using both plasma 25-hydroxyvitamin D (25 (OH) D) and 1,25-dihydroxyvitamin D (1,25 (OH) 2D) biomarkers. Vitamin D biomarker levels and leukocyte telomere length were measured using plasma samples collected in 1989-1990 from participants of the Nurses'Health Study, a study of nurses from 11 US states. In total, 1,424 participants had their 25 (OH) D levels assessed and 837 had their 1,25 (OH) 2D levels assessed. Genotyping was performed on 480 participants on 12 single nucleotide polymorphisms in vitamin D-related genes. Linear and logistic regression models were used. Higher 25 (OH) D levels were significantly associated with longer telomere length (P for trend=0.05), and the odds ratio increased from 1.07 (P=0.65) when comparing the second lowest quartile of 25 (OH) D with the lowest to 1.59 (P=0.01) when comparing the highest quartile with the lowest. Vitamin D-related single nucleotide polymorphisms and 1,25 (OH) 2D levels were not significantly associated with telomere length. Total calcium intake significantly modified the association between 25 (OH) D and telomere length (P for interaction=0.05). Higher plasma 25 (OH) D levels may be associated with longer telomeres, and this association may be modified by calcium intake.
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