Titre : | Seasonal Variation in 25-Hydroxyvitamin D Concentrations in the Cardiovascular Health Study. (2011) |
Auteurs : | SHOBEN (Abigail-B) : USA. Division of Biostatistics. College of Public Health. Ohio State University. Columbus. OH. ; Ian-H DE BOER ; HOOFNAGLE (Andrew-N) : USA. Department of Laboratory Medicine. University of Washington. Seattle. WA. ; Bryan KESTENBAUM ; Gregory Levin ; Bruce-M PSATY ; David-S SISCOVICK ; Cardiovascular Health Research Unit. Departments of Medicine and Epidemiology. University of Washington. Seattle. WA. USA ; Kidney Research Institute. Division of Nephrology. Departments of Medicine and Epidemiology. University of Washington. Seattle. WA. USA |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 174, n° 12, 2011) |
Pagination : | 1363-1372 |
Langues: | Anglais |
Mots-clés : | Variation saisonnière ; Concentration ; Appareil cardiovasculaire ; Phosphatase alcaline ; Saison ; Vitamine D ; Epidémiologie ; Enzyme |
Résumé : | [BDSP. Notice produite par INIST-CNRS 7pEq8R0x. Diffusion soumise à autorisation]. Low circulating concentrations of 25-hydroxyvitamin D (25 (OH) D) are associated with adverse health outcomes in diverse populations. However, 25 (OH) D concentrations vary seasonally with varying exposure to sunlight, so single measurements may poorly reflect long-term 25 (OH) D exposure. The authors investigated cyclical trends in average serum 25 (OH) D concentrations among 2,298 individuals enrolled in the Cardiovascular Health Study of community-based older adults (1992-1993). A sinusoidal model closely approximated observed 25 (OH) D concentrations and fit the data significantly better than did a mean model (P |