Résumé :
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[BDSP. Notice produite par INIST-CNRS 8rFGR0x7. Diffusion soumise à autorisation]. Glioma risk has consistently been inversely associated with allergy history but not with smoking history despite putative biologic plausibility. Data from 855 high-grade glioma cases and 1,160 controls from 4 geographic regions of the United States during 1997-2008 were analyzed for interactions between allergy and smoking histories and inherited variants in 5 established glioma risk regions : 5p15.3 (TERT), 8q24.21 (CCDC26/MLZE), 9p21.3 (CDKN28), 11q23.3 (PHLDB1/DDX6), and 20q13.3 (RTEL1). The inverse relation between allergy and glioma was stronger among those who did not (odds ratioallergy-glioma=0.40,95% confidence interval : 0.28,0.58) versus those who did (odds ratioallergy-glioma=0.76,95% confidence interval : 0.59,0.97 ; Pinteraction=0.02) carry the 9p21.3 risk allele. However, the inverse association with allergy was stronger among those who carried (odds ratioallergy-glioma=0.44,95% confidence interval : 0.29,0.68) versus those who did not carry (odds ratioanergy-glioma=0.68,95% confidence interval : 0.54,0.86) the 20q13.3 glioma risk allele, but this interaction was not statistically significant (P=0.14). No relation was observed between glioma risk and smoking (odds ratio=0.92,95% confidence interval : 0.77,1.10 ; P=0.37), and there were no interactions for glioma risk of smoking history with any of the risk alleles. The authors'observations are consistent with a recent report that the inherited glioma risk variants in chromosome regions 9p21.3 and 20q13.3 may modify the inverse association of allergy and glioma.
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