Titre : | Variations in Apolipoprotein E Frequency With Age in a Pooled Analysis of a Large Group of Older People. (2011) |
Auteurs : | Gareth-J MCKAY ; Goncalo-R ABECASIS ; Paul-N BAIRD ; Usha CHAKRAVARTHY ; Valentina CIPRIANI ; Shilpa DASARI ; Paulus-Tdv DE JONG ; Michael DEAN ; Sarah ENNIS ; Astrid-E FLETCHER ; Peter-J FRANCIS ; Lars-G FRITSCHE ; Michael-B GORIN ; Robyn-H GUYMER ; Caroline HAYWARD ; Aroon-D HINGORANI ; Lintje HO ; Atsuhiro KANDA ; Claudia-N KEILHAUER ; Caroline-C KLAVER ; Michael-L Klein ; Chia-Ling KUO ; Andrew-J LOTERY ; Anthony-T MOORE ; Anton ORLIN ; Mohammad OTHMAN ; Chris-C PATTERSON ; Inga PETER ; Mati RAHU ; Julie SAWITZKE ; Johanna-M SEDDON ; Johan-H SELAND ; Giuliana SILVESTRI ; Reecha SOFAT ; Gisele SOUBRANE ; Dwight STAMBOLIAN ; Anand SWAROOP ; Laura TOMAZZOLI ; Fotis TOPOUZIS ; Johannes-R VINGERLING ; Jesus VIOQUE ; Bernhard-H Weber ; Andrew-R WEBSTER ; Daniel-E WEEKS ; . WEI CHEN ; Alan-F WRIGHT ; John-R YATES ; Ian-S YOUNG ; Centre for Eye Research Australia. Royal Victorian Eye and Ear Hospital. University of Melbourne. East Melbourne. Victoria. AUS ; Centre for Public Health. Queen's University Belfast. Belfast Northern Ireland. GBR ; Centre for Vision and Vascular Science. Queen's University Belfast. Belfast Northern Ireland. GBR ; Department of Ophthalmology. University of Pennsylvania. Philadelphia. PA. USA ; Institute of Human Genetics. University of Regensburg. Regensburg. DEU ; Macular Degeneration Center. Casey Eye Institute. Oregon Health and Science University. Portland. OR. USA |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 173, n° 12, 2011) |
Pagination : | 1357-1364 |
Langues: | Anglais |
Mots-clés : | Fréquence ; Age ; Personne âgée ; Longévité ; Epidémiologie ; Homme |
Résumé : | [BDSP. Notice produite par INIST-CNRS AR0xDAn8. Diffusion soumise à autorisation]. Variation in the apolipoprotein E gene (APOE) has been reported to be associated with longevity in humans. The authors assessed the allelic distribution of APOE isoforms epsilon2, E3, and E4 among 10,623 participants from 15 case-control and cohort studies of age-related macular degeneration (AMD) in populations of European ancestry (study dates ranged from 1990 to 2009). The authors included only the 10,623 control subjects from these studies who were classified as having no evidence of AMD, since variation within the APOE gene has previously been associated with AMD. In an analysis stratified by study center, gender, and smoking status, there was a decreasing frequency of the APOE epsilon4 isoform with increasing age (khi2 for trend=14.9 (1 df) ; P=0.0001), with a concomitant increase in the epsilon3 isoform (khi2 for trend=11.3 (1 df) ; P=0.001). The association with age was strongest in epsilon4 homozygotes ; the frequency of epsilon4 homozygosity decreased from 2.7% for participants aged 60 years or less to 0.8% for those over age 85 years, while the proportion of participants with the epsilon3/epsilon4 genotype decreased from 26.8% to 17.5% across the same age range. Gender had no significant effect on the isoform frequencies. This study provides strong support for an association of the APOE gene with human longevity. |