Titre : | Parkinson's Disease and Residential Exposure to Maneb and Paraquat From Agricultural Applications in the Central Valley of California. (2009) |
Auteurs : | COSTELLO (Sadie) : USA. Department of Environmental Health Sciences. School of Public Health. University of California. Berkeley. Berkeley. CA. ; BRONSTEIN (Jeff) : USA. Department of Neurology. School of Medicine. University of California. Los Angeles. CA. ; Myles COCKBURN ; RITZ (Beate) : USA. Department of Epidemiology. School of Public Health. University of California. Los Angeles. CA. ; . XINBO ZHANG ; Department of Geography. College of Letters. Arts and Sciences. University of Southern California. Los Angeles. CA. USA |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 169, n° 8, 2009) |
Pagination : | 919-926 |
Langues: | Anglais |
Mots-clés : | Domicile ; Santé environnementale ; Agriculture ; Enquête cas témoin ; Epidémiologie ; Industrie ; Homme ; Amérique ; Pesticide ; Maladie dégénérative ; Amérique du Nord |
Résumé : | [BDSP. Notice produite par INIST-CNRS HICCFR0x. Diffusion soumise à autorisation]. Evidence from animal and cell models suggests that pesticides cause a neurodegenerative process leading to Parkinson's disease (PD). Human data are insufficient to support this claim for any specific pesticide, largely because of challenges in exposure assessment. The authors developed and validated an exposure assessment tool based on geographic information systems that integrated information from California Pesticide Use Reports and land-use maps to estimate historical exposure to agricultural pesticides in the residential environment. In 1998-2007, the authors enrolled 368 incident PD cases and 341 population controls from the Central Valley of California in a case-control study. They generated estimates for Maneb and paraquat exposures incurred between 1974 and 1999. Exposure to both pesticides within 500 m of the home increased PD risk by 75% (95% confidence interval (Cl) : 1.13,2.73). Persons aged |