Résumé :
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[BDSP. Notice produite par INIST-CNRS GR0xlID8. Diffusion soumise à autorisation]. The etiology of myelodysplastic syndromes (MDS) is not well understood. The authors examined the relations of obesity and lifestyle factors to MDS in a cohort of 471,799 persons aged 50-71 years who were recruited into the National Institutes of Health-AARP Diet and Health Study, a large US prospective study, in 1995-1996. Incident MDS was diagnosed in 193 persons during 2001-2003. A significant positive association was observed between body mass index (BMI ; weight (kg)/height (m) 2) at baseline and MDS. Compared with persons with a BMI less than 25.0, the hazard ratios for persons with BMIs of 25.0-=30.0 were 1.15 (95% confidence interval (CI) : 0.81,1.64) and 2.18 (95% CI : 1.51,3.17 ; Pfor trend
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