Résumé :
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[BDSP. Notice produite par INIST-CNRS Dno8R0xF. Diffusion soumise à autorisation]. Previous studies suggest that birth weight and weight gain during the first year of life are related to later risk of type 1 diabetes. The authors performed a systematic review and meta-analysis on these associations. Twelve studies involving 2,398,150 persons of whom 7,491 had type 1 diabetes provided odds ratios and 95% confidence intervals of type 1 diabetes associated with birth weight. Four studies provided data on weight and/or weight gain during the first year of life. High birth weight (>4,000 g) was associated with increased risk of type 1 diabetes (odds ratio=1.17,95% confidence interval (Cl) : 1.09,1.26). According to sensitivity analysis, this result was not influenced by particular study characteristics. The pooled confounder-adjusted estimate was 1.43 (95% Cl : 1.11,1.85). No heterogeneity was found (/2=0%) and no publication bias. Low birth weight (
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