Titre : | Use of A Mendelian Randomization Approach to Assess the Causal Relation of gamma-Glutamyltransferase with Blood Pressure and Serum Insulin Levels. (2010) |
Auteurs : | CONEN (David) : CHE. Department of Medicine. University Hospital Basel. Basel. ; Murielle BOCHUD ; Pedro MARQUES-VIDAL ; Fred PACCAUD ; Valentin ROUSSON ; Peter VOLLENWEIDER ; Gérard WAEBER ; Department of Medicine. Centre Hospitalier Universitaire Vaudois and University of Lausanne. Lausanne. CHE ; Institute of Social and Preventive Medicine. Centre Hospitalier Universitaire Vaudois and University of Lausanne. Lausanne. CHE |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 172, n° 12, 2010) |
Pagination : | 1431-1441 |
Langues: | Anglais |
Mots-clés : | Diabète ; Obésité ; Utilisation ; Randomisation ; Facteur ; Pression artérielle ; Insuline ; Epidémiologie ; Enzyme ; Glande endocrine [pathologie] |
Résumé : | [BDSP. Notice produite par INIST-CNRS R0xJDmH9. Diffusion soumise à autorisation]. Elevated levels of gamma-glutamyltransferase (GGT) have been associated with elevated blood pressure (BP) and diabetes. However, the causality of these relations has not been addressed. The authors performed a cross-sectional analysis (2003-2006) among 4,360 participants from the population-based Cohorte Lausannoise (CoLaus) Study (Lausanne, Switzerland). The rs2017869 variant of the gamma-glutamyltransferase 1 (GGT1) gene, which explained 1.6% of the variance in GGT levels, was used as an instrument for Mendelian randomization (MR). Sex-specific GGT quartiles were strongly associated with both systolic and diastolic BP (all P's |