Titre : | Bowel Movement and Constipation Frequencies and the Risk of Colorectal Cancer Among Men in the Netherlands Cohort Study on Diet and Cancer. (2010) |
Auteurs : | Colinda-Cjm SIMONS ; GOLDBOHM (Ralexandra) : NLD. Department of Prevention and Health. Tno Quality of Life. Netherlands Organisation for Applied Scientific Research. Leiden. ; Leo-J SCHOUTEN ; Piet-A VAN DEN BRANDT ; Matty-P WEIJENBERG ; Department of Epidemiology. Grow School for Oncology and Developmental Biology. Maastricht University. Maastricht. NLD |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 172, n° 12, 2010) |
Pagination : | 1404-1414 |
Langues: | Anglais |
Mots-clés : | Constipation ; Cancer ; Intestin ; Fréquence ; Facteur risque ; Risque ; Homme ; Régime alimentaire ; Rectum ; Epidémiologie ; Europe ; Côlon |
Résumé : | [BDSP. Notice produite par INIST-CNRS kR0xDJjl. Diffusion soumise à autorisation]. The authors investigated the associations between bowel movement and constipation frequencies and colorectal cancer (CRC) endpoints among men in the Netherlands Cohort Study on Diet and Cancer (n=58,279) and explored whether dietary fiber intake may modify associations. After 13.3 years (1986-1999), 1,207 CRC cases and 1,753 subcohort members were available for case-cohort analyses. Multivariate analyses showed a significantly increased hazard ratio for CRC overall and rectal cancer in men who reported having a bowel movement 1-2 times per day (second-highest category) as compared with once a day (CRC : hazard ratio (HR)=1.29,95% confidence interval (CI) : 1.09,1.53 (Ptrend |