Résumé :
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[BDSP. Notice produite par INIST-CNRS R0xG8sDH. Diffusion soumise à autorisation]. This study examined prepregnancy cardiometabolic risk factors and gestational diabetes mellitus (GDM) in subsequent pregnancies. The authors selected 1,164 women without diabetes before pregnancy who delivered 1,809 live births between 5 consecutive examinations from 1985 to 2006 in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. The authors measured prepregnancy cardiometabolic risk factors and performed multivariate repeated-measures logistic regression to compute the odds of GDM adjusted for race, age, parity, birth order, and other covariates. Impaired fasting glucose (100-125 vs.15-20 and>20 vs.50 mg/dL) before pregnancy were directly associated with GDM : The odds ratios=4.74 (95% confidence interval (CI) : 2.14,10.51) for fasting glucose, 2.19 (95% CI : 1.15,4.17) for middle insulin levels and 2.36 (95% CI : 1.20,4.63) for highest insulin levels, and 3.07 (95% CI : 1.62,5.84) for low levels of high-density lipoprotein cholesterol among women with a negative family history of diabetes ; all P
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