Résumé :
|
[BDSP. Notice produite par INIST-CNRS Bp8R0x89. Diffusion soumise à autorisation]. Serum gamma-glutamyl transferase (GGT), a marker of oxidative stress, has been shown to be associated with diabetes mellitus in some population-based studies, but not all. Also, it is not clear if there is a continuous dose-response relationship in this association, or if this association is evident only beyond a particular threshold level of GGT. We examined the association between serum GGT and diabetes mellitus in a representative sample of US adults aged>20 years, in a cross-sectional study involving 7,976 National Health and Nutrition Examination Survey 1999-2002 participants. Diabetes mellitus was defined as a fasting glucose>=126mg/dl, nonfasting glucose>200 mg/d1, or use of oral hypoglycemic medication or insulin (n=805). Higher serum GGT levels were positively associated with diabetes mellitus, independent of, alcohol consumption, body mass index, hypertension and other confounders. Multivariable odds ratio (95% confidence interval) comparing quartile 4 of GGT (>33 U/L) to quartile 1 (
|