Résumé :
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[BDSP. Notice produite par INIST-CNRS HR0xrHFm. Diffusion soumise à autorisation]. The authors determined the association between metabolic syndrome in early pregnancy (mean, 11.96 weeks) and the risk of preterm birth in the mother-child cohort study ("Rhea" Study) in Crete, Greece, 2007-2009. Maternal fasting serum samples were collected, and blood pressure was measured at the time of the first major ultrasound examination (n=625). Multivariable log-binomial regression models were used. Women with metabolic syndrome were at high risk for preterm birth (relative risk (RR)=2.93,95% confidence interval (CI) : 1.53,5.58), with the highest risk observed for medically indicated preterm births (RR=5.13,95% CI : 1.97,13.38). Among the components of metabolic syndrome, the most significant risk factor was hypertension (RR=2.32,95% CI : 1.28,4.20). An elevation of 10 mm Hg in diastolic blood pressure increased the relative risk for preterm birth by 29% (RR=1.29,95% CI : 1.08,1.53), while a per unit increase in the low density lipoprotein/high density lipoprotein cholesterol ratio increased this risk by 19% (RR=1.19,95% CI : 1.02,1.39). Fetal weight growth restriction was associated with elevated levels of insulin (RR=1.14,95% CI : 1.08,1.20) and diastolic blood pressure (RR=1.27,95% CI : 1.00,1.61) in early pregnancy. These findings suggest that women with metabolic syndrome in early pregnancy had higher risk for preterm birth.
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