Titre : | Diurnal cortisol patterns are associated with physical performance in the Caerphilly Prospective Study. (2011) |
Auteurs : | Michael-P GARDNER ; BAYER (Antony) : GBR. Section of Geriatric Medicine. Cardiff University School of Medicine. ; Yoav BEN-SHLOMO ; EBRAHIM (Shah) : GBR. London School of Hygiene and Tropical Medicine. London. ; GALLACHER (John) : GBR. Department of Primary Care and Public Health. Cardiff University. ; Rebecca Hardy ; Diana KUH ; LIGHTMAN (Stafford-L) : GBR. Henry Wellcome Laboratories for Integrative Neuroscience and Endocrinology. Bristol. ; Mrc Unit for Lifelong Health and Ageing and Division of Population Health. University College London. GBR ; School of Social and Community Medicine. University of Bristol. Canynge Hall. Bristol. GBR |
Type de document : | Article |
Dans : | International journal of epidemiology (vol. 40, n° 6, 2011) |
Pagination : | 1693-1702 |
Langues: | Anglais |
Mots-clés : | Association ; Pays de Galles ; Etude prospective ; Médicament antiinflammatoire ; Grande Bretagne ; Europe ; Corticostéroïde ; Vieillissement |
Résumé : | [BDSP. Notice produite par INIST-CNRS tBR0xGsE. Diffusion soumise à autorisation]. Background Cross-sectional studies have suggested that elevated cortisol is associated with worse physical performance, a surrogate of ageing. We examined the relationship between repeat cortisol measures over 20 years and physical performance in later life. Methods Middle-aged men (45-59 years) were recruited between 1979 and 1983 (Phase 1) from the Caerphilly Prospective Study (CaPS) and re-examined 20 years later at 65-83 years of age (Phase 5). Participants included 750 and 898 subjects with either Phase 1 and/or Phase 5 data on exposure and outcomes. Outcome measures were walking speed and balance time and exposures included morning fasting serum cortisol (Phase 1) and four salivary samples on 2 consecutive days (Phase 5). Results Faster walking speed was associated with higher morning cortisol at Phase 1 [coefficient per standard deviation (SD) increase 0.68,95 % confidence interval (95 % CI) 0.09-1.27 ; P =0.02] though this was attenuated after adjustment for covariates (coefficient per SD increase 0.45 ; 95 % CI - 0.16 to 1.07 ; P =0.15). Higher night-time cortisol at Phase 5 was associated with slower speed (coefficient per SD increase - 1.06 ; 95 % CI - 1.60 to - 0.52 ; P |