Titre : | Joint Associations Between Genetic Variants and Reproductive Factors in Glioma Risk Among Women. (2011) |
Auteurs : | WANG (Sophia-S) : USA. Division of Cancer Etiology. Department of Population Sciences. Beckman Research Institute and the City of Hope. Duarte. CA. ; Michael ALAVANJA ; Laura BEANE-FREEMAN ; Amanda BLACK ; Tania CARREON ; Stephen-J CHANOCK ; Patricia HARTGE ; Ann-W HSING ; Peter-D INSKIP ; Martha LINET ; Preetha RAJARAMAN ; Avima-M RUDER ; Mahboobeh SAFAIEAN ; Meredith YEAGER ; Core Genotyping Facility. Division of Cancer Epidemiology and Genetics. National Cancer Institute. Gaithersburg. MD. USA ; Division of Surveillance. Hazard Evaluations. And Field Studies. National Institute for Occupational Safety and Health. Centers for Disease Control and Prevention. Cincinnati. OH. USA |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 174, n° 8, 2011) |
Pagination : | 901-908 |
Langues: | Anglais |
Mots-clés : | Risque cumulé ; Facteur associé ; Association ; Reproduction ; Facteur risque ; Risque ; Femme ; Gène ; Génétique ; Epidémiologie ; Homme ; Tumeur |
Résumé : | [BDSP. Notice produite par INIST-CNRS 7R0xAIFt. Diffusion soumise à autorisation]. In a pooled analysis of 4 US epidemiologic studies (1993-2001), the authors evaluated the role of 5 female reproductive factors in 357 women with glioma and 822 controls. The authors further evaluated the independent association between 5 implicated gene variants and glioma risk among the study population, as well as the joint associations of female reproductive factors (ages at menarche and menopause, menopausal status, use of oral contraceptives, and menopausal hormone therapy) and these gene variants on glioma risk. Risk estimates were calculated as odds ratios and 95% confidence intervals that were adjusted for age, race, and study. Three of the gene variants (rs4295627, a variant of CCDC26 ; rs4977756, a variant of CDKN2A and CDKN2B ; and rs6010620, a variant of RTEL 1) were statistically significantly associated with glioma risk in the present population. Compared with women who had an early age at menarche ( |