| Titre : | A prospective study of body mass index and mortality in Bangladesh. (2010) |
| Auteurs : | Brandon-L PIERCE ; Alauddin AHMED ; AHSAN (Habibul) : USA. Departments of Medicine and Human Genetics and Cancer Research Center. The University of Chicago. Chicago. IL. ; Maria ARGOS ; Joseph GRAZIANO ; Rabiul HASAN ; Tariqul ISLAM ; Tara KALRA ; Faruque PARVEZ ; Muhammad RAKIBUZ-ZAMAN ; Paul-J RATHOUZ ; YU CHEN (.) : USA. Department of Environmental Medicine. New York University. New York. NY. ; Columbia University and University of Chicago Research Office in Bangladesh. Mohakhali. Dhaka. BGD ; Department of Health Studies. The University of Chicago. Chicago. IL. USA |
| Type de document : | Article |
| Dans : | International journal of epidemiology (vol. 39, n° 4, 2010) |
| Pagination : | 1037-1045 |
| Langues: | Anglais |
| Mots-clés : | Etude prospective ; Mortalité ; Epidémiologie ; Arsenic ; Survie ; Asie |
| Résumé : | [BDSP. Notice produite par INIST-CNRS FDG9nR0x. Diffusion soumise à autorisation]. Background Body mass index (BMI) (kg/m2) has a U-or J-shaped relationship with all-cause mortality in Western and East Asian populations. However, this relationship is not well characterized in Bangladesh, where the BMI distribution is shifted towards lower values. Methods Using data on 11445 individuals (aged 18-75 years) participating in the Health Effects of Arsenic Longitudinal Study (HEALS) in Araihazar, Bangladesh, we prospectively examined associations of BMI (measured at baseline) with all-cause mortality during 6 years of follow-up. We also examined this relationship within strata of key covariates (sex, age, smoking, education and arsenic exposure). Cox proportional hazards models adjusted for these covariates and BMI-related illnesses were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for BMI categories defined by the World Health Organization. Results Low BMI was strongly associated with increased mortality in this cohort (P-trend<0.0001). Severe underweight (BMI<16 kg/m2 ; HR 2.06, CI 1.53-2.77) and moderate underweight (16.0-16.9 kg/m2 ; HR 1.39, CI 1.01-2.90) were associated with increased all-cause mortality compared with normal BMI (18.6-22.9 kg/m2). The highest BMI category (>=23.0 kg/m2) did not show a clear association with mortality (HR 1.10, CI 0.77-1.53 The BMI-mortality association was stronger among individuals with<5 years of formal education (interaction P=0.02). Conclusions Underweight (presumably due to malnutrition) is a major determinant of mortality in the rural Bangladeshi population. |
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