Titre : | Effects of Folic Acid Supplementation on Serum Folate and Plasma Homocysteine Concentrations in Older Adults : A Dose-Response Trial. (2010) |
Auteurs : | Cheryl-Am ANDERSON ; APPEL (Lawrence-J) : USA. Division of General Internal Medicine. School of Medicine. Johns Hopkins University. Baltimore. MD. ; Jeanne CHARLESTON ; NARRETT (Matthew) : USA. Renaissance Gardens at Charlestown. Catonsville. MD. ; SUN HA JEE (.) : KOR. Department of Epidemiology and Health Promotion. School of Public Health. Yonsei University. Yonsei. |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 172, n° 8, 2010) |
Pagination : | 932-941 |
Langues: | Anglais |
Mots-clés : | Vitamine ; Nutrition ; Supplémentation ; Sérum ; Folate ; Plasma sanguin ; Concentration ; Personne âgée ; Dosage ; Essai thérapeutique ; Procès ; Adulte ; Alimentation ; Aliment ; Epidémiologie ; Homme |
Résumé : | [BDSP. Notice produite par INIST-CNRS BImtR0xC. Diffusion soumise à autorisation]. The authors'objective in this study was to estimate the changes in serum folate and homocysteine concentration that resulted from 6 weeks of supplementation with folic acid. A randomized, double-blind, placebo-controlled, dose-response trial with a parallel-group design was conducted. A total of 133 participants aged 60-90 years (70% female, 19% nonwhite) were assigned to receive 0,100,400,1,000, or 2,000 mug/day of folic acid for 6 weeks. Data were collected in the United States between June and September 1996. At baseline, median serum folate and plasma homocysteine concentrations were 5.7 ng/mL (interquartile range (25th-75th percentiles), 4.1-7.8) and 8.3 mumol/L (interquartile range, 7.1-10.0), respectively. As the folic acid dose increased, serum folate levels increased (P-trend |