Titre : | Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals. (2010) |
Auteurs : | Esther-H LIPS ; Antonio AGUDO ; Luigi BARZAN ; Vladimir BENCKO ; Simone Benhamou ; Paolo BOFFETTA ; Maiken BRATT ELVESTAD ; Paul BRENNAN ; Cristina CANOVA ; Xavier CASTELLSAGUE ; Amélie Chabrier ; David-I CONWAY ; Maria-Paula CURADO ; Jose ELUF-NETO ; Eleonora FABIANOVA ; Leticia Fernandez ; John-K FIELD ; Lenka FORETOVA ; Valerie GABORIEAU ; Mia HASHIBE ; Claire HEALY ; Simon HEATH ; Ivana HOLCATOVA ; Rayjean-J HUNG ; Kristian HVEEM ; Vladimir JANOUT ; Kristina KJAERHEIM ; Sergio KOIFMAN ; Pagona LAGIOU ; Mark LATHROP ; Triantafillos LILOGLOU ; Jolanta LISSOWSKA ; Geoffrey LIU ; Ray LOWRY ; Tatiana-V MACFARLANE ; Dana MATES ; Elena MATOS ; James-D MCKAY ; John MCLAUGHLIN ; Ana MENEZES ; Franco MERLETTI ; Andres METSPALU ; Peter RUDNAI ; Frank SKORPEN ; Neonilia SZESZENIA-DABROWSKA ; Lars VATTEN ; George XINARIANOS ; David ZARIDZE ; Ariana ZNAOR ; Institute of Hygiene and Epidemiology. First Faculty of Medicine and General University Hospital. Charles University. Prague. CZE ; Norwegian University of Science and Technology. Trondheim. NOR ; Roy Castle Lung Cancer Research Programme. University of Liverpool Cancer Research Centre. Liverpool. GBR ; Samuel Lunenfeld Research Institute of the Mount Sinai Hospital. Toronto. CAN |
Type de document : | Article |
Dans : | International journal of epidemiology (vol. 39, n° 2, 2010) |
Pagination : | 563-577 |
Langues: | Anglais |
Mots-clés : | Tabagisme ; Association ; Gène ; Cancer ; Génétique ; Tabac ; Homme |
Résumé : | [BDSP. Notice produite par INIST-CNRS FECR0xn9. Diffusion soumise à autorisation]. Background Genetic variants in 15q25 have been identified as potential risk markers for lung cancer (LC), but controversy exists as to whether this is a direct association, or whether the 15q variant is simply a proxy for increased exposure to tobacco carcinogens. Methods We performed a detailed analysis of one 15q single nucleotide polymorphism (SNP) (rs16969968) with smoking behaviour and cancer risk in a total of 17 300 subjects from five LC studies and four upper aerodigestive tract (UADT) cancer studies. Results Subjects with one minor allele smoked on average 0.3 cigarettes per day (CPD) more, whereas subjects with the homozygous minor AA genotype smoked on average 1.2 CPD more than subjects with a GG genotype (P20 CPD) [odds ratio (OR)=1.13,95% confidence interval (CI) 0.96-1.34, P=0.13 for heterozygotes and 1.81,95% CI 1.39-2.35 for homozygotes, P |