Résumé :
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[BDSP. Notice produite par INIST-CNRS E79CR0xk. Diffusion soumise à autorisation]. Background We undertook a systematic review and meta-analysis of perinatal variables in relation to testicular cancer risk, with a specific focus upon characteristics of the mother. Methods EMBASE, PubMed, Scopus and Web of Science databases were searched using sensitive search strategies. Meta-analysis was undertaken using STATA 10. Results A total of 5865 references were retrieved, of which 67 met the inclusion criteria and contributed data to at least one perinatal analysis. Random effects meta-analysis found maternal bleeding during pregnancy [odds ratio (OR) 1.33,95% confidence interval (CI) 1.02-1.73], birth order (primiparous vs not, 1.08,95% CI 1.01-1.16 ; second vs first, OR 0.94,95% CI 0.88-0.99 ; third vs first, OR 0.91,95% CI 0.83-1.01 ; fourth vs first, OR 0.80,95% CI 0.69-0.94) and sibship size (2 vs 1, OR 0.93,95% CI 0.75-1.15 ; 3 vs 1, OR 0.89,95% CI 0.74-1.07 ; 4 vs 1, OR 0.75,95% CI 0.62-0.90) to be associated with testicular cancer risk. Meta-analyses that produced summary estimates which indicated no association included maternal age, maternal nausea, maternal hypertension, pre-eclampsia, breech delivery and caesarean section. Meta-regression provided evidence that continent of study is important in the relationship between caesarean section and testicular cancer (P=0.035), and a meta-analysis restricted to the three studies from the USA was suggestive of association (OR 1.67,95% CI 1.07-2.56). Conclusions This systematic review and meta-analysis has found evidence for associations of maternal bleeding, birth order, sibship size and possibly caesarean section with risk of testicular cancer.
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