Titre :
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A meta-analysis of the association between day-care attendance and childhood acute lymphoblastic leukaemia : Cancer. (2010)
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Auteurs :
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Kevin-Y URAYAMA ;
AYOOB (Julie-M) : USA. School of Nursing. University of California. San Francisco. CA. ;
Patricia-A BUFFLER ;
GALLAGHER (Emily-R) : USA. Seattle Children's Hospital. University of Washington. Seattle. WA. ;
XIAOMEI MA (.) : USA. Yale University School of Medicine. New Haven. CT.
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Type de document :
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Article
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Dans :
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International journal of epidemiology (vol. 39, n° 3, 2010)
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Pagination :
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718-732
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Langues:
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Anglais
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Mots-clés :
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Association
;
Hôpital jour
;
Enfant
;
Infection
;
Epidémiologie
;
Enquête cas témoin
;
Homme
;
Cancer
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Résumé :
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[BDSP. Notice produite par INIST-CNRS ml8CER0x. Diffusion soumise à autorisation]. Background Childhood acute lymphoblastic leukaemia (ALL) may be the result of a rare response to common infection (s) acquired by personal contact with infected individuals. A meta-analysis was conducted to examine the relationship between day-care attendance and risk of childhood ALL, specifically to address whether early-life exposure to infection is protective against ALL. Methods Searches of the PubMed database and bibliographies of publications on childhood leukaemia and infections were conducted. Observational studies of any size or location and published in English resulted in the inclusion of 14 case-control studies. Results The combined odds ratio (OR) based on the random effects model indicated that day-care attendance is associated with a reduced risk of ALL [OR=0.76,95% confidence interval (CI) : 0.67,0.87]. In subgroup analyses evaluating the influence of timing of exposure, a similarly reduced effect was observed for both day-care attendance occurring early in life (
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