Titre :
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Birth weight and risk of neuroblastoma : a meta-analysis : Cancer. (2010)
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Auteurs :
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Thomas HARDER ;
HARDER (Anja) : DEU. Department of Neuropathology. Charité-Universitätsmedizin Berlin. Berlin. ;
Andreas PLAGEMANN ;
Clinic of Obstetrics. Division of Experimental Obstetrics. Charité-Universitdtsmedizin Berlin. Berlin. DEU
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Type de document :
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Article
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Dans :
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International journal of epidemiology (vol. 39, n° 3, 2010)
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Pagination :
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746-756
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Langues:
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Anglais
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Mots-clés :
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Poids naissance
;
Mesure risque
;
Enfant
;
Nourrisson
;
Homme
;
Cancer
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Résumé :
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[BDSP. Notice produite par INIST-CNRS HkR0x9GJ. Diffusion soumise à autorisation]. Background Neuroblastoma is the most common solid tumour in infancy but its aetiology is largely unknown. Prenatal factors might play a key role in its pathogenesis. Previous studies investigated whether birth weight is associated with risk of neuroblastoma, with conflictive results. We conducted a meta-analysis to quantitatively summarize the published evidence. Methods Results from 10 case-control studies and one cohort study (1966 to December 2008) were included, involving a total of 3004 children with neuroblastoma. We constructed random-effects and fixed-effects models, performed'pool-first'analyses, assessed heterogeneity and publication bias and performed sensitivity and influence analyses. Results High birth weight (>4000g) was associated with increased risk of neuroblastoma [odds ratio (OR) 1.19 ; 95% confidence interval (CI) 1.04-1.36]. Results for high birth weight were highly homogenous (I2=0%). Low birth weight (
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