| Titre : | Circulating C-Reactive Protein Concentrations and Risks of Colon and Rectal Cancer : A Nested Case-Control Study Within the European Prospective Investigation into Cancer and Nutrition. (2010) |
| Auteurs : | Krasimira ALEKSANDROVA ; Naomi-E ALLEN ; Aurelio BARRICARTE ; H. BAS BUENO-DE-MESQUITA ; Heiner BOEING ; Catalina BONET ; Marie-Christine BOUTRON-RUAULT ; Francoise CLAVEL-CHAPELON ; Christina-C DAHM ; Miren DORRONSORO ; Goran HALLMANS ; Eugene JANSEN ; Mazda JENAB ; Rudolf KAAKS ; Kay-Tee KHAW ; Vittorio KROGH ; Pagona LAGIOU ; Anke-M LEUFKENS ; Sophie MOROIS ; Carmen NAVARRO ; Teresa NORAT ; Anja OLSEN ; Kim OVERVAD ; Domenico PALLI ; Richard PALMQVIST ; Salvatore PANICO ; Petra-H PEETERS ; Tobias PISCHON ; Elio RIBOLI ; Sabina RINALDI ; Laudina RODRIGUEZ ; Sabine ROHRMANN ; Dora ROMAGUERA ; Maria-José SANCHEZ ; Elizabeth SPENCER ; Anne TJONNELAND ; Dimitrios TRICHOPOULOS ; Antonia TRICHOPOULOU ; Rosario TUMINO ; Fränzel-Jb VAN DUIJNHOVEN ; Paolo VINEIS ; Nicholas WAREHAM |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 172, n° 4, 2010) |
| Pagination : | 407-418 |
| Langues: | Anglais |
| Mots-clés : | Cancer ; Hyperglycémie ; Hyperlipidémie ; Obésité ; Concentration ; Facteur risque ; Risque ; Enquête cas témoin ; Epidémiologie ; Europe ; Etude prospective ; Alimentation ; Nutrition ; Inflammation ; Abdomen ; Lipide ; Glande endocrine [pathologie] |
| Résumé : | [BDSP. Notice produite par INIST-CNRS rkR0xH8A. Diffusion soumise à autorisation]. The authors investigated associations between serum C-reactive protein (CRP) concentrations and colon and rectal cancer risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (1992-2003) among 1,096 incident cases and 1,096 controls selected using risk-set sampling and matched on study center, age, sex, time of blood collection, fasting status, menopausal status, menstrual cycle phase, and hormone replacement therapy. In conditional logistic regression with adjustment for education, smoking, nutritional factors, body mass index, and waist circumference, CRP showed a significant nonlinear association with colon cancer risk but not rectal cancer risk. Multivariable-adjusted relative risks for CRP concentrations of>=3.0 mg/L versus<1.0 mg/L were 1.36 (95% confidence interval (CI) : 1.00,1.85 ; P-trend=0.01) for colon cancer and 1.02 (95% CI : 0.67,1.57 ; P-trend=0.65) for rectal cancer. Colon cancer risk was significantly increased in men (relative risk=1.74,95% CI : 1.11,2.73 ; P-trend=0.01) but not in women (relative risk=1.06,95% CI : 0.67,1.68 ; P-trend=0.13). Additional adjustment for C-peptide, glycated hemoglobin, and high density lipoprotein cholesterol did not attenuate these results. |
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