Titre : | Apolipoprotein E gene is related to mortality only in normal weight individuals : The Rotterdam study. (2008) |
Auteurs : | Mcarolina PARDO SILVA ; Albert HOFMAN ; JANSSENS (Acecile-Jw) : NLD. Department of Public Health. Erasmus Mc University Medical Center Rotterdam. Rotterdam. ; Cornelia-M VAN DUIJN ; Jacqueline-Cm WITTEMAN ; Department of Epidemiology & Biostatistics. Erasmus Mc University Medical Center Rotterdam. Rotterdam. NLD |
Type de document : | Article |
Dans : | European journal of epidemiology (vol. 23, n° 2, 2008) |
Pagination : | 135-142 |
Langues: | Anglais |
Mots-clés : | Gène ; Hypercholestérolémie ; Génétique ; Mortalité ; Epidémiologie ; Homme ; Cholestérol ; Lipoprotéine ; Europe ; Lipide ; Hyperlipoprotéinémie |
Résumé : | [BDSP. Notice produite par INIST-CNRS R0x7ggRq. Diffusion soumise à autorisation]. Objective To investigate the relationship between the apolipoprotein E (APOE) gene and the risk of mortality in normal weight, overweight and obese individuals. Methods and Results In a population-based study of 7,983 individuals aged 55 years and older, we compared the risks of all-cause and coronary heart disease (CHD) mortality by APOE genotype, both overall and in subgroups defined by body mass index (BMI). We found significant evidence for interaction between APOE and BMI in relation to total cholesterol (p=0.04) and HDL cholesterol (p |