Résumé :
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[BDSP. Notice produite par INIST-CNRS sAjqR0xA. Diffusion soumise à autorisation]. Older adults are vastly underrepresented in clinical trials in spite of shouldering a disproportionate burden of disease and consumption of prescription drugs and therapies, restricting treatments'generalizability, efficacy, and safety. Eliminating Disparities in Clinical Trials, a national initiative comprising a stake-holder network of researchers, community advocates, policymakers, and federal representatives, undertook a critical analysis of older adults'structural barriers to clinical trial participation. We present practice and policy change recommendations emerging from this process and their rationale, which spanned multiple themes : (1) decision making with cognitively impaired patients ; (2) pharmacokinetic differences and physiological age ; (3) health literacy, communication, and aging ; (4) geriatric training ; (5) federal monitoring and accountability ; (6) clinical trial costs ; and (7) cumulative effects of aging and ethnicity.
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