Titre :
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Synergistic effect of the genetic polymorphisms of the renin-angiotensin-aldosterone system on high-altitude pulmonary edema : a study from Qinghai-Tibet altitude. (2008)
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Auteurs :
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. YUE QI ;
. CHANGCHUN QIU ;
TONGCHUN ZHU (.) : CHN. Hospital of China Railway Construction Corporation. Geermu Qing Hai Province. ;
. WENQUAN NIU ;
. WENYU ZHOU ;
National Laboratory of Medical Molecular Biology. Institute of Basic Medical Sciences. Chinese Academy of Medical Sciences. Peking Union Medical College. Beijing. CHN
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Type de document :
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Article
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Dans :
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European journal of epidemiology (vol. 23, n° 2, 2008)
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Pagination :
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143-152
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Langues:
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Anglais
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Mots-clés :
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Synergie
;
Génétique
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Altitude
;
Homme
;
Epidémiologie
;
Chine
;
Asie
;
Elément environnement
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Résumé :
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[BDSP. Notice produite par INIST-CNRS 1fn39R0x. Diffusion soumise à autorisation]. The pathogenesis of high-altitude pulmonary edema (HAPE) has been at least partially attributed to the local dysregulation of the renin-angiotensin-aldosterone system (RAAS) cascade. To address this issue, we conducted the largest nested case-control study to-date to explore the association between variations in RAAS genes and HAPE in Chinese population. We recruited 140 HAPE patients and 144 controls during the construction of Qinghai-Tibet railway and genotyped 10 gene polymorphisms evenly interspersed in 5 RAAS candidate genes. The data were analyzed by haplotype and multifactor dimensionality reduction (MDR). The single-locus analysis showed that CYP11B2 C-344T and K173R and ACE A-240T polymorphisms were significantly associated with HAPE after Bonferroni correction (P
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