Résumé :
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[BDSP. Notice produite par INIST-CNRS HR0xs9lk. Diffusion soumise à autorisation]. Most gallstones originate from cholesterol-supersaturated bile. Statins inhibit hepatic cholesterol biosynthesis and therefore may reduce the risk of gallstone disease. Population-based evidence, however, is sparse. Thus, the authors conducted a population-based case-control study using medical databases from northern Denmark (1.7 million inhabitants) to identify 32,494 cases of gallstones occurring between 1996 and 2008 and to identify age-sex-and county-matched population controls for each case. Cases and their matched controls who were exposed to lipid-lowering drugs were categorized as current users if their last prescription was redeemed=20 total prescriptions. In former users, the corresponding adjusted odds ratios were 1.24 (95% CI : 1.11,1.39), 0.97 (95% CI : 0.86,1.10), and 0.79 (95% CI : 0.64,0.97), respectively. The use of other lipid-lowering drugs showed no similar association.
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