Résumé :
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[BDSP. Notice produite par INIST-CNRS mI8R0x8D. Diffusion soumise à autorisation]. Using 1996-2000 data among Connecticut women, the authors evaluated whether genetic variation in 4 metabolic genes modifies organic solvent associations with non-Hodgkin lymphoma and 5 major histologic subtypes. Pinteraction values were determined from cross-product terms between dichotomous (ever/never) solvent variables and genotypes at examined loci in unconditional logistic regression models. The false discovery rate method was used to account for multiple comparisons. Overall associations between the chlorinated solvents dichloromethane (odds ratio (OR)=1.69,95% confidence interval (CI) : 1.06,2.69), carbon tetrachloride (OR=2.33,95% CI : 1.23,4.40), and methyl chloride (OR=1.44,95% CI : 0.94,2.20) and total non-Hodgkin lymphoma were increased among women TT for rs2070673 in the cytochrome P4502E1 gene, CYP2E1 (dichloromethane : OR=4.42,95% CI : 2.03,9.62 ; Pinteraction
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