Résumé :
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[BDSP. Notice produite par INIST-CNRS Y8rR0xw0. Diffusion soumise à autorisation]. Little is known about the dietary patterns associated with colorectal tumors along the adenoma-carcinoma sequence. Scores for dietary patterns were obtained by factor analysis in women from the French cohort of the European Prospective Investigation into Cancer and Nutrition (1993-2000). Their association with colorectal tumors was investigated in 516 adenoma cases (175 high-risk adenomas) and 4,804 polyp-free women and in 172 colorectal cancer cases and 67,312 cancer-free women. The authors identified four dietary patterns : "healthy" (vegetables, fruit, yogurt, sea products, and olive oil) ; "Western" (potatoes, pizzas and pies, sandwiches, sweets, cakes, cheese, cereal products, processed meat, eggs, and butter) ; "drinker" (sandwiches, snacks, processed meat, and alcoholic beverages) ; and "meat eaters" (meat, poultry, and margarine). For quartile 4 versus quartile 1, an increased risk of adenoma was observed with high scores of the Western pattern (multivariate relative risk (RR)=1.39,95% confidence interval : 1.00,1.94 ; ptend=0.03) and the drinker pattern (RR=1.42,95% confidence interval : 1.10,1.83 ; ptrend=0.01). The meat-eaters pattern was positively associated with colorectal cancer risk (for quartile 4 vs. quartile 1 : RR=1.58,95% confidence interval : 0.98,2.53 ; ptrend=0.02). Dietary patterns that reflect a Western way of life are associated with a higher risk of colorectal tumors.
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