| Titre : | Preclinical Serum 25-Hydroxyvitamin D Levels and Risk of Type 1 Diabetes in a Cohort of US Military Personnel. (2013) |
| Auteurs : | Kassandra-L MUNGER ; ASCHERIO (Alberto) : USA. Channing Laboratory. Department of Medicine. Brigham and Women's Hospital. And Harvard Medical School. Harvard University. Boston. MA. ; HORST (Ronald) : USA. Heartland Assays. Ames. IA. ; Lynn-I Levin ; Jennifer MASSA ; ORBAN (Tihamer) : USA. Orban Biotech. Llc. Boston. MA. ; Department of Epidemiology. Harvard School of Public Health. Harvard University. Boston. MA. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 177, n° 5, 2013) |
| Pagination : | 411-419 |
| Langues: | Anglais |
| Mots-clés : | Sérum ; Facteur risque ; Risque ; Maladie autoimmune ; Homme ; Militaire ; Personnel ; Enquête cas témoin ; Epidémiologie ; Vitamine D ; Amérique ; Glande endocrine [pathologie] ; Immunopathologie ; Amérique du Nord |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xErEGo. Diffusion soumise à autorisation]. To determine whether serum levels of 25-hydroxyvitamin D (25 (OH) D) in young adults are associated with risk of type 1 diabetes mellitus (T1D), we conducted a prospective, nested case-control study among US active-duty military personnel with serum in the US Department of Defense Serum Repository, identifying 310 T1D cases diagnosed between 1997 and 2009 with at least 2 serum samples collected before disease onset and 613 controls matched to cases on age, sex, race/ethnicity, branch of military service, and dates of serum collection. Conditional logistic regression was used to estimate rate ratios and 95% confidence intervals. Among non-Hispanic whites, those with average 25 (OH) D levels of>=100 nmol/L had a 44% lower risk of developing T1D than those with average 25 (OH) D levels<75 nmol/L (rate ratio=0.56,95% confidence interval : 0.35,0.90, P for trend=0.03) over an average follow-up of 5.4 years. In quintile analyses, T1D risk was highest among individuals whose 25 (OH) D levels were in the lowest 20% of those measured. There was no association between 25 (OH) D levels and risk of T1D among non-Hispanic blacks or Hispanics. Low 25 (OH) D levels may predispose healthy, young, non-Hispanic white adults to the development of T1D. |
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