Résumé :
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[BDSP. Notice produite par INIST-CNRS 899oFR0x. Diffusion soumise à autorisation]. The beneficial biologic effects attributed to vitamin D suggest a potential to influence overall mortality. Evidence addressing this hypothesis is limited, especially for African Americans who have a high prevalence of vitamin D insufficiency. The authors conducted a nested case-control study within the prospective Southern Community Cohort Study to relate baseline serum levels of 25-hydroxyvitamin D (25 (OH) D) with subsequent mortality. Cases were 1,852 participants who enrolled from 2002 to 2009 and died>12 months postenrollment. Controls (n=1,852) were matched on race, sex, age, enrollment site, and blood collection date. The odds ratios for quartile 1 (21.64 ng/mL) levels of 25 (OH) D were 1.60 (95% confidence interval (CI) : 1.20,2.14) for African Americans and 2.11 (95% CI : 1.39,3.21) for non-African Americans. The effects were strongest for circulatory disease death, where quartile 1 versus quartile 4 odds ratios were 2.53 (95% CI : 1.44,4.46) and 3.25 (95% CI : 1.33,7.93) for African Americans and non-African Americans, respectively. The estimated odds of total mortality were minimized in the 25 (OH) D range of 35-40 ng/mL. These findings provide support for the hypothesis that vitamin D status may have an important influence on mortality for both African Americans and non-African Americans.
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