Résumé :
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[BDSP. Notice produite par INIST-CNRS IssonR0x. Diffusion soumise à autorisation]. Association of urinary arsenic concentration with incident diabetes was examined in American Indians from Arizona who have a high prevalence of type 2 diabetes and were screened for diabetes between 1982 and 2007. The population resides where drinking water contains arsenic at concentrations above federally recommended limits. A total of 150 nondiabetic subjects aged>=25 years who subsequently developed type 2 diabetes were matched by year of examination and sex to 150 controls who remained nondiabetic for>=10 years. Total urinary arsenic concentration, adjusted for urinary creatinine level, ranged from 6.6 mug/L to 123.1 mug/L, and inorganic arsenic concentration ranged from 0.1 mug/L to 36.0 mug/L. In logistic regression models adjusted for age, sex, body mass index, and urinary creatinine level, the odds ratios for incident diabetes were 1.11 (95% confidence interval (CI) : 0.79,1.57) and 1.16 (95% CI : 0.89,1.53) for a 2-fold increase in total arsenic and inorganic arsenic, respectively. Categorical analyses suggested a positive relationship between quartiles of inorganic arsenic and incident diabetes (P=0.056) ; post-hoc comparison of quartiles 2-4 with quartile 1 revealed 2-fold higher odds of diabetes in the upper quartiles (OR=2.14,95% CI : 1.19,3.85). Modestly elevated exposure to inorganic arsenic may predict type 2 diabetes in American Indians. Larger studies that include measures of speciated arsenic are required for confirmation.
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