| Titre : | Calcium and vitamin D intake and risk of colorectal cancer : The multiethnic cohort study. (2007) |
| Auteurs : | Song-Yi PARK ; HENDERSON (Brian-E) : USA. Department of Preventive Medicine. Keck School of Medicine. University of Southern California. Los Angeles. CA. ; Laurence-N KOLONEL ; Suzanne-P MURPHY ; Abraham-My NOMURA ; Lynne-R WILKENS ; University of Hawaii. Cancer Research Center of Hawaii. Cancer Epidemiology Program. Honolulu. HI. USA |
| Type de document : | Article |
| Dans : | American journal of epidemiology (vol. 165, n° 7, 2007) |
| Pagination : | 784-793 |
| Langues: | Anglais |
| Mots-clés : | Calcium ; Vitamine D ; Facteur risque ; Risque ; Ethnie ; Produit laitier ; Alimentation ; Supplémentation ; Epidémiologie ; Homme ; Appareil digestif [pathologie] ; Intestin [pathologie] ; Cancer |
| Résumé : | [BDSP. Notice produite par INIST-CNRS R0xsipcB. Diffusion soumise à autorisation]. The associations of intakes of calcium and vitamin D with colorectal cancer risk were examined in the Multiethnic Cohort Study (Hawaii and Los Angeles, California). In 1993-1996,85,903 men and 105,108 women aged>45 years completed a quantitative food frequency questionnaire. A total of 2,110 incident cases of colorectal cancer (1,138 in men and 972 in women) were identified through December 31,2001. Cox proportional hazards models were used to calculate multivariate-adjusted relative risks and 95% confidence intervals. Total calcium intake (from foods and supplements) was inversely associated with colorectal cancer risk in both men (highest quintile vs. lowest : relative risk (RR)=0.70,95% confidence interval (Cl) : 0.52,0.93 ; p for trend=0.006) and women (RR=0.64,95% Cl : 0.50,0.83 ; p for trend=0.003). The inverse association was also seen for total vitamin D intake in men (RR=0.72,95% Cl : 0.51,1.00 ; p for trend=0.03) but not in women. Intake of dairy products was inversely associated with colorectal cancer risk, especially among nonusers of supplemental calcium (men : RR=0.77,95% Cl : 0.59,1.01 ; women : RR=0.66,95% Cl : 0.49,0.89). The findings support the hypothesis of protective roles for calcium, vitamin D, and dairy products in the risk of colorectal cancer. |
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