Titre : | Serum antibody response to periodontal pathogens and herpes simplex virus in relation to classic risk factors of cardiovascular disease. (2006) |
Auteurs : | VILKUNA-RAUTIAINEN (Tiina) : FIN. Institute of Dentistry. University of Helsinki. ; ASIKAINEN (Sirkka) : SWE. Oral Microbiology. Department of Odontology. Faculty of Medicine and Odontology. Ume ? University. ; Tapani HOVI ; Pekka JOUSILAHTI ; PETAYS (Tuula) : FIN. Helsinki University Central Hospital. Division of Allergy. Helsinki. ; PUSSINEN (Pirkko-J) : FIN. Department of Oral and Maxillofacial Diseases. Helsinki University Central Hospital. Helsinki. ; Merja ROIVAINEN ; Erkki VARTIAINEN |
Type de document : | Article |
Dans : | International journal of epidemiology (vol. 35, n° 6, 2006) |
Pagination : | 1486-1494 |
Langues: | Anglais |
Mots-clés : | Appareil circulatoire [pathologie] ; Facteur risque ; Epidémiologie ; Anticorps ; Virus ; Parodontopathie ; Herpès ; Virose ; Infection ; Finlande ; Europe ; Homme ; Stomatologie |
Résumé : | [BDSP. Notice produite par INIST-CNRS vrFPR0x6. Diffusion soumise à autorisation]. Background : Increasing evidence links chronic infections, especially burden of several infections, with increased risk for cardiovascular diseases (CVD). We studied joint immune response against two major periodontal pathogens and herpes simplex virus (HSV) in relation to established risk factors of CVD. Methods : Serum antibody levels to HSV, Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis were determined by ELISA. The study included 1107 subjects, 734 from Finland and 373 from Russia. Results : Combined antibody response to periodontal pathogens was associated inversely (OR, 95% CI) with high-density lipoprotein (HDL) cholesterol concentration (bêta=0.35 ; 0.20,0.60 ; P |