Résumé :
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[BDSP. Notice produite par INIST-CNRS nkH8R0xJ. Diffusion soumise à autorisation]. Because pesticides may operate through different mechanisms, the authors studied the risk of prostate cancer associated with specific pesticides in the Agricultural Health Study (1993-2007). With 1,962 incident cases, including 919 aggressive prostate cancers among 54,412 applicators, this is the largest study to date. Rate ratios and 95% confidence intervals were calculated by using Poisson regression to evaluate lifetime use of 48 pesticides and prostate cancer incidence. Three organophosphate insecticides were significantly associated with aggressive prostate cancer : fonofos (rate ratio (RR) for the highest quartile of exposure (Q4) vs. nonexposed=1.63,95% confidence interval (CI) : 1.22,2.17 ; Ptrend
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