Titre : | Toenail Nicotine Level as a Novel Biomarker for Lung Cancer Risk. (2011) |
Auteurs : | AL-DELAIMY (Wael-K) : USA. Department of Family and Preventive Medicine. School of Medicine. University of California. San Diego. San Diego. CA. ; WILLETT (Walter-C) : USA. Department of Epidemiology. Harvard School of Public Health. Boston. MA. |
Type de document : | Article |
Dans : | American journal of epidemiology (vol. 173, n° 7, 2011) |
Pagination : | 822-828 |
Langues: | Anglais |
Mots-clés : | Nicotine ; Facteur risque ; Risque ; Ongle ; Tabac ; Epidémiologie ; Alcaloïde ; Cancer |
Résumé : | [BDSP. Notice produite par INIST-CNRS sR0xE78A. Diffusion soumise à autorisation]. The objective of this US study was to assess the association of toenail nicotine level as a novel biomarker with lung cancer risk independent of reported smoking history. A nested case-control study of 210 male lung cancer cases and 630 matched controls aged 40-75 years participating in the Health Professionals Follow-up Study was conducted. Toenail samples collected in 1987 were analyzed for nicotine levels, and incident lung cancer cases were diagnosed between 1988 and 2000. Mean toenail nicotine level among cases was 0.95 ng/mg compared with 0.25 ng/mg among controls (P |